tert-butyl 4-(2-nitrophenoxy)piperidine-1-carboxylate

tert-butyl 4-(2-nitrophenoxy)piperidine-1-carboxylate - Names and Identifiers

Name	tert-butyl 4-(2-nitrophenoxy)piperidine-1-carboxylate
Synonyms	BOC-4-(2-NITROPHENOXY)PIPERIDINE 4-(2-NITROPHENOXY)PIPERIDINE, N-BOC PROTECTED Tert-butyl4-(2-nitrophenoxy)piperidine-1-carboxylate tert-butyl 4-(2-nitrophenoxy)piperidine-1-carboxylate TERT-BUTYL 4-(2-NITROPHENOXY)PIPERIDINE-1-CARBOXYLATE tert-Butyl 4-(2-nitrophenoxy)piperidine-1-carboxylate 4-(2-nitrophenoxy)-piperidine-1-carboxylic acid tert-butyl ester TERT-BUTYL 4-(2-NITROPHENOXY)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE tert-butyl 4-(2-nitrophenoxy)tetrahydro-1(2H)-pyridinecarboxylate 1-piperidinecarboxylic acid, 4-(2-nitrophenoxy)-, 1,1-dimethylethyl ester 1-Piperidinecarboxylic acid, 4-(2-nitrophenoxy)-, 1,1-dimethylethyl ester
CAS	690632-03-2
InChI	InChI=1/C16H22N2O5/c1-16(2,3)23-15(19)17-10-8-12(9-11-17)22-14-7-5-4-6-13(14)18(20)21/h4-7,12H,8-11H2,1-3H3

tert-butyl 4-(2-nitrophenoxy)piperidine-1-carboxylate - Physico-chemical Properties

Molecular Formula	C16H22N2O5
Molar Mass	322.36
Density	1.211±0.06 g/cm3(Predicted)
Melting Point	91 °C
Boling Point	447.3±35.0 °C(Predicted)
Flash Point	224.327°C
Vapor Presure	0mmHg at 25°C
pKa	-2.56±0.40(Predicted)
Storage Condition	2-8°C
Refractive Index	1.546

tert-butyl 4-(2-nitrophenoxy)piperidine-1-carboxylate - Risk and Safety

Hazard Symbols	Xi - Irritant
Hazard Note	Irritant

tert-butyl 4-(2-nitrophenoxy)piperidine-1-carboxylate - Introduction

tert-butyl 4-(2-nitrophenoxy)piperidine-1-carboxylate is an organic compound with the chemical formula C15H22N2O4.

Nature:
1. Appearance: white crystalline powder.
2. Melting point: about 85-87°C.
3. Solubility: Soluble in organic solvents such as ethanol and dichloromethane.

Use:
1. tert-butyl 4-(2-nitrophenoxy)piperidine-1-carboxylate are commonly used as intermediates in organic synthesis.
2. It is used in the field of medicinal chemistry to synthesize biologically active compounds, such as potential drugs in the field of medicine.
3. It can be used as one of the raw materials for pesticides and insecticides.

Preparation Method:
The preparation method of tert-butyl 4-(2-nitrophenoxy)piperidine-1-carboxylate is relatively simple, and a commonly used synthetic route is as follows:
1.4-hydroxy benzoic acid tert-butyl ester is reacted with 2-nitrobromobenzene to generate 4-(2-nitrophenoxy) benzoic acid tert-butyl ester.
2. The above product is hydrogenated under the catalysis of hydrogen and Pd/C to obtain tert-butyl 4-(2-nitrophenoxy) benzoate.
3. Finally, the above compound is reacted with pyridine under appropriate conditions to prepare the tert-butyl 4-(2-nitrophenoxy)piperidine-1-carboxylate.

Safety Information:
tert-butyl the safety of 4-(2-nitrophenoxy)piperidine-1-carboxylate is relatively high, as an organic compound, it still needs to be used with caution. When handling, should follow the general laboratory safety procedures, and avoid contact with skin, inhalation or ingestion. In the case of accidental exposure or misuse, medical help should be sought immediately and a safety data sheet for this compound should be presented to the physician.

Last Update：2024-04-09 21:00:56